Fibromyalgia (FM) is often considered a diagnosis of exclusion — meaning there’s no single definitive test, and it’s typically diagnosed after other conditions have been ruled out. Clinically, FM is described as a central sensitivity syndrome, where hallmark symptoms stem from abnormal processing in the central nervous system.
The Nervous System Meets the Immune System
Emerging research is uncovering an important connection between the central nervous system and the immune systemin the inflammatory processes underlying chronic pain, fatigue, and cognitive changes — the classic signs of FM. This growing understanding has given rise to a new field of study: neuroimmunology, which examines how these two systems interact and influence one another.
Cytokines, Chemokines, and Chronic Pain
Recent studies have found lower concentrations of neurologically derived inflammatory markers — called cytokines and chemokines — in the blood of those with Fibromyalgia.
Cytokines and chemokines are protein messengers that coordinate communication between the nervous and immune systems.
Under stress, these messengers stimulate physiological responses to help the body adapt.
Lower levels in FM sufferers suggest reduced stress resilience, which may contribute to abnormal responses to mental, physical, and chemical stressors — ultimately fueling the chronic fatigue, cognitive impairment, and hypersensitivity associated with the condition.
Stress, Adaptability, and the Central Nervous System
In a healthy system, stress triggers a coordinated effort between the central nervous system and endocrine system, allowing the body to adapt.
But in FM, this coordination appears diminished, limiting the body’s ability to respond effectively. This impaired adaptability can weaken innate immunity — the body’s first line of defense — and lead to heightened sensitivity and pain.
Hope in New Testing and Treatment Approaches
A simple blood test can now detect abnormal levels of these neuroimmune signaling proteins. This can help guide interventions aimed at improving central nervous system adaptability and restoring healthier stress responses.
The Role of Upper Cervical Care
Upper cervical doctors offer a unique perspective by focusing on the structural health of the spine and its impact on nervous system function. Since the spine and central nervous system operate as a functional unit, the old adage “structure determines function” is especially relevant.
Improving spinal alignment may support better central nervous system performance — potentially benefiting not only FM sufferers, but also those with related conditions such as Parkinson’s disease, Alzheimer’s, Multiple Sclerosis, and sensory processing disorders. These functional deficits can arise at any age, making early detection and support vital.
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